Vincent Poitout, DVM, PhD
Professor of Medicine, Nutrition and Biochemistry
Scientific Director, CRCHUM
Canada Research Chair in Diabetes and Pancreatic β-cell Function
MDRC Co-Director/UdeM and Associate Director/Research
Dr Vincent Poitout received his Doctorate in Veterinary Medicine
from the École Nationale Vétérinaire d'Alfort in 1991 and his PhD degree from the
Université Paris 6 in 1993. He did a post-doctoral fellowship at the University of
Minnesota, Minneapolis, MN, under the guidance of Dr Paul Robertson between 1993
and 1995. He was then recruited as a scientist at the French national institutes of
health research (INSERM) and worked at the Hôtel-Dieu hospital in Paris, France.
In 1998 Dr Poitout was recruited as Principal Scientist at the Pacific Northwest
Research Institute in Seattle, WA, USA. He was also appointed Affiliate Assistant
Professor of Medicine at the University of Washington in Seattle, WA in 2000. In
2005, Dr Poitout was recruited as Associate Professor of Medicine, Nutrition, and
Biochemistry at the University of Montréal, QC, Canada, and his laboratory is located
within the Montréal Diabetes Research Center at the Centre de Recherche du Centre
Hospitalier de l'Université de Montréal at the Technopole Angus. In 2007, he was
appointed as Associate Scientific Director – Basic Research at the Centre de Recherche
du CHUM, and he was also appointed as Full Professor of Medicine in 2008. Dr Poitout
is the former Chair of the American Diabetes Association's Grant Review Panel, a
former member of the Editorial Board of Endocrinology and a current Editorial
Board member of Diabetes and The Journal of Biological Chemistry.
Dr Poitout's research is funded by the US National Institutes of
Health, the Canadian Institutes of Health Research and the Canadian Diabetes
Association. Dr Poitout received several awards including the Albert Renold Fellowship
from the European Association for the Study of Diabetes, the Jean Leray Award from
the European Society for Biomaterials, the Thomas R. Lee Career Development Award
from the American Diabetes Association, and the Apollinaire Bouchardat Award from
the Journées Annuelles de Diabétologie de l'Hôtel-Dieu.
Dr Poitout holds the Canada Research Chair in Diabetes and Pancreatic ß-cell Function
Click here for pdf CV
Our group is involved with 4 research projects:
1- Mechanisms by which fatty acids acutely stimulate
insulin secretion, and more precisely the role of the GPR40 receptor.
Using GPR40 knock-out mice, we have shown that GPR40 mediates approximately 50%
of the stimulatory effect of fatty acids on insulin secretion in vitro
and in vivo, but is not implicated in their long-term, deleterious
effects on ß-cell function.
2- We are studying the molecular
mechanisms by which chronic fatty acids inhibit insulin gene expression. We
have shown that this involves a blockade of the nuclear translocation of the
transcription factor Pdx-1, as well as reduced expression of the transcription factor
MafA. We are currently investigating the signaling pathways involved in palmitate
inhibition of insulin gene expression.
3- We have established an in vivo
model of nutrient excess by chronic perfusion in the rat. In collaboration
with the group of Marc Prentki, we are now examining the effects of age and genetic
predisposition on the development of diabetes in this model.
4- In collaboration with the group of Richard
Smith at the Pacific Northwest National Laboratories in Richmond, WA, we are carrying
out a study which aims to perform proteomics and metabolomics profiling of
isolated human islets and to determine if changes in these global profiles
correlate with islet function in vitro and in vivo, to establish
predictive criteria of islet function prior to transplantation.
Click here for PubMed listing