Pierre Haddad, PhD
Professor of Pharmacology
Pierre S. Haddad was trained in pharmacology at Université de
Montréal where he obtained a PhD degree in 1986 under the direction of Dr Marielle
Gascon-Barré. His first postdoctoral fellowship was carried out at the Institute of
General and Experimental Pathology at the University of Vienna, Austria, on the ionic
movements involved in cell volume regulation in liver under the supervision of Prof.
Jürg Graf in 1986-1988. He continued this work in the laboratory of Prof. James L.
Boyer at the Yale University Liver Center, USA from 1988-1990. He then returned to
the Department of Pharmacology at Université de Montréal to establish an independent
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Selected Scientific Contributions
Since the beginning of his career as an independent investigator,
Dr Haddad developed two major areas of research. The first addressed the cellular and
molecular effects of cold preservation-warm reperfusion (CI/WR) on liver cells,
notably on membrane transport systems regulating cell volume, pH and calcium. The
second research focus of his laboratory concerns anti-diabetic medicinal plants.
Building from an initial expertise in the cellular and molecular actions of insulin
on hepatocytes, he developed an elaborate platform of in vitro bioassays and
in vivo animal models to thoroughly assess the antidiabetic potential of
selected medicinal plants, notably from the Mediterranean region and the Boreal forest
of Canada. Since 2003, he leads the CIHR Team in Aboriginal Antidiabetic Medicines.
The project aims at rigorously studying plants used by Elders and healers of Eeyou
Istchee (Canadian James Bay Cree) that have promising anti-diabetic potential. This
multidisciplinary project involves ethnobotany, phytochemistry, nutrition, pharmacology,
toxicology, clinical trials and health services and aims to prepare standardized
phytomedicinal preparations to be clinically tested by Cree diabetics and integrate
Cree traditional medicine into diabetes health care. His laboratory has thus become
a Canadian reference for rigorous scientific evaluation of natural health products.
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Actions of drugs, antioxidant vitamins and natural health products
on non-alcoholic steatohepatitis. In vitro and in vivo evaluation
of the bioactivity and therapeutic potential of natural health products in the
metabolic syndrome and diabetes.